|
T9929 |
Ramucirumab
|
|
VEGFR
|
|
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. |
|
T10777 |
CG347B
|
|
HDAC
|
|
CG347B is a selective inhibitor of HDAC6. |
|
T21588 |
Olomoucine
|
|
ERK
,
CDK
|
|
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an... |
|
T2325 |
Neratinib
|
HKI-272 |
EGFR
,
HER
|
|
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively. |
|
T9865 |
Almonertinib mesylate
|
|
EGFR
|
|
Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st... |
|
T8756 |
KRAS inhibitor-9
|
DUN09716 |
Apoptosis
,
Ras
|
|
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ... |
|
T60076 |
Oritinib
|
SH-1028 |
EGFR
|
|
Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can ... |
|
T5462 |
Almonertinib
|
HS-10296 |
EGFR
|
|
Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR. |
|
T5675 |
Almonertinib hydrochloride
|
HS-10296 hydrochloride |
EGFR
|
|
Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. |
|
T8656 |
CAY10404
|
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis
,
Akt
,
COX
|
|
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel... |
|
T0373 |
Erlotinib
|
OSI-744,NSC 718781,CP358774,R1415 |
EGFR
,
Autophagy
|
|
Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. |
|
T1758 |
ABT-751
|
E7010 |
Microtubule Associated
,
Autophagy
|
|
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. |
|
T15390 |
Glufosfamide
|
D 19575,Glucosylifosfamide mustard |
Others
|
|
Glufosfamide is a novel oxazolophosphamide compound with anticancer activity for the study of advanced non-small cell lung cancer. |
|
T30087 |
Antroquinonol
|
|
Reactive Oxygen Species
,
Nrf2
|
|
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segment... |
|
T36404L |
PRLX-93936 HCL
|
PRLX-93936 hcl(903499-49-0 Free base) |
Ferroptosis
,
Reactive Oxygen Species
|
|
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin. |
|
T39275 |
Befotertinib
|
D-0316,Befotertinib |
EGFR
|
|
Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer. |
|
T0373L |
Erlotinib hydrochloride
|
OSI-744,NSC 718781,Erlotinib HCl,CP-358774 |
EGFR
,
Autophagy
|
|
Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. |
|
T67934 |
MRT-2359
|
|
Others
|
|
MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits... |
|
T9673 |
RET-IN-3
|
|
c-RET
|
|
RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer. |
|
T6084 |
Rabusertib
|
LY2603618,IC-83 |
Chk
,
PDK
,
Autophagy
|
|
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance... |
|
T72043 |
SCFSkp2-IN-2
|
|
Apoptosis
,
E1/E2/E3 Enzyme
|
|
SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells. |
|
T76792 |
Sibrotuzumab
|
BIBH 1,Anti-Human FAP Recombinant Antibody |
Others
|
|
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal cancer and non-small cell lung cancer. |
|
T40292 |
Opnurasib
|
NVP-JDQ443,JDQ-443,Opnurasib |
Ras
|
|
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer. |
|
T35901 |
EGFR-IN-99
|
JBJ-03-142-02 |
EGFR
,
HER
|
|
EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC). |
|
T13564L2 |
AZ7550 trimesylate salt
|
AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base) |
MLK
|
|
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer. |
|
T9901A-002 |
Enoblituzumab
|
MGA271,TJ-271 |
Others
|
|
Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung cancer (NSCLC). |
|
T61016 |
EMI1
|
|
EGFR
|
|
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1]. |
|
T35391 |
Vibostolimab (anti-TIGIT)
|
Vibostolimab (anti-TIGIT) |
Others
|
|
Vibostolimab is a monoclonal antibody against T cell immune proteins and the ITIM domain.Vibostolimab has shown anti-tumor activity in in vitro trials and can be used to study non-small cell lung cancer (NSCLC) and melan... |
|
T9754 |
BLU-945
|
BLU945,BLU 945 |
EGFR
|
|
BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797... |
|
T76796 |
Patritumab
|
U3-1287,AMG-888 |
ERK
,
EGFR
,
Akt
,
HER
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-sm... |
|
T36316 |
MTOR inhibitor-8
|
mTOR-IN-8 |
mTOR
,
Autophagy
|
|
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. |
|
T60039 |
KSQ-4279
|
USP1-IN-1 |
PARP
,
DUB
|
|
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
|
T35394 |
Sintilimab (anti-PD-1)
|
IBI308,Sintilimab (anti-PD-1) |
PD-1/PD-L1
|
|
Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding to PD-1 and thereby blocking the interaction of PD-1 with i... |
|
T9460 |
IMDK
|
|
PI3K
|
|
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou... |
|
T35392 |
Tiragolumab
|
RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058 |
Others
|
|
Tiragolumab(MTIG-7192A) is a monoclonal antibody that targets T-cell immunoglobulin and the ITIM structural domain (TIGIT).Tiragolumab is often used in combination with the PD-L1 inhibitor, Atezolizumab, for the treatmen... |
|
T14997 |
Conteltinib
|
SY-707,CT-707 |
FAK
,
PYK2
,
ALK
|
|
Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carci... |
|
T72953 |
Zidesamtinib
|
NVL-520 |
ROS Kinase
|
|
Zidesamtinib (NVL-520) is an orally active, selective, potent, and blood-brain-barrier-crossing inhibitor of ROS1 fusion and resistance mutations, inhibits ROS1 and ROS1 G2032R, and can be used in the study of non-small-... |
|
T72784 |
OTUB1/USP8-IN-1
|
|
DUB
|
|
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung c... |
|
T63343 |
ULK1-IN-2
|
|
Apoptosis
,
Autophagy
|
|
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.... |
|
T2490 |
Osimertinib
|
AZD-9291,Mereletinib |
EGFR
|
|
Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activi... |
|
T61575 |
USP15-IN-1
|
|
DUB
|
|
USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can pr... |
|
T22443 |
Triglycidyl isocyanurate
|
Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI |
Apoptosis
|
|
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk... |
|
T77401 |
Bavituximab
|
Anti-PS MAb 3G4 |
Others
|
|
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to ... |
|
T11067 |
VX-984
|
M9831 |
DNA-PK
|
|
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo... |
|
T0189L |
Pemetrexed disodium
|
LY-231514,LY231514 disodium,Pemetrexed |
Apoptosis
,
DHFR
,
DNA/RNA Synthesis
,
Antifolate
,
Autophagy
|
|
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has b... |
|
T69529 |
BI-0474
|
|
Ras
|
|
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G... |
|
T11126 |
Durvalumab
|
MEDI 4736 |
PD-1/PD-L1
|
|
Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combinat... |
|
T9972 |
Divarasib
|
GDC-6036 |
Ras
|
|
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibi... |
|
T76873 |
Nidanilimab
|
CAN04 |
IL Receptor
|
|
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr... |
|
T64529 |
MDL-800
|
MDL 800,MDL800 |
Sirtuin
|
|
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. |
